Archiv Jochen-Kalden-Förderprogramm
Overview of completed projects
Cell-cell communication through miR containing exosomes, autophagy and circulating factors in rare glomerular diseases
Term: 01.04.2021 – 31.12.2024
I investigate rare glomerular diseases with different cell culture models, transgenic zebrafish models, podocyte specific knockout models, innovative techniques, interdisciplinary collaborations and patient material to cover multidimensional aspects of the disease in a patient centered manner. Cell-cell signaling through miRs, exosomes, autophagy and circulating factors are investigated to learn more about pathomechanisms of rare glomerular diseases that might translate into novel therapeutic targets in the future.
The role of lysosomal dysfunction within glial cells in Parkinson’s disease
Term: 16.02.2021 – 15.11.2024
Recent studies suggest that glial dysfunction significantly contributes to neurodegeneration in Parkinson’s disease (PD). Since lysosomal degradation is important for glial cell function, we aim to analyse the molecular consequences of lysosomal dysfunction within different glial cell lines. A better understanding of glial regulation and lysosomal turnover will help to unravel molecular mechanisms in PD and might facilitate the identification of novel therapeutic strategies in PD.
