N10 LAMP1+ neutrophils in lupus nephritis (Grieshaber-Bouyer)
LAMP1+ neutrophils in lupus nephritis
Term: 01.07.2024 – 30.06.2026
My preliminary data highlight that neutrophil phenotypes define distinct SLE patients and that LAMP-1 is a strongly dysregulated protein in SLE. I hypothesize that LAMP1 expression defines a distinct activation state of neutrophils associated with a clinical subgroup of SLE patients with more severe kidney involvement. Hence, this project aims to study the functional
role of LAMP1 in neutrophils and probe associations of LAMP1 expression and serum levels with clinical features in SLE.
