N12 Autoimmunity therapies and T cell function (Nganou Makamdop)
T cell plasticity and functionality under conventional autoimmune disease therapies
Term: 01.04.2025 – 31.03.2027
The proposed project will investigate the effect of common therapies such as hydroxychloroquine, tocilizumab, mycophenolate mofetil or rituximab in systemic lupus and systemic sclerosis patients.
Closing a major gap in our knowledge of how distinct therapies influence T cell differentiation, metabolic reprogramming, subsets distribution and effector functions; this study will guide the improvement of disease management to favour immune competence.
